The BizTalk360 Database can be treated as a normal database and as such you can choose how to backup, and which recovery model to use,and Including the BizTalk360 database backup in the BizTalk backup is also acceptable.
Please find the steps to Take Backup of BizTalk360 Database:
1. Go to BizTalk360 Database.
2. Select and right click, choose task and Backup
3. From there a new window will be pop-up.
4. Choose the Destination path where the Backup file need to be stored.
5. Click OK, Backup will be taken accordingly.